Asthma hu-mouse models 

Involvement of Immune Cells in Asthma

  • Allergen captured by DC
  • DC present antigen to T cells to induce Th2
  • Th2 promote IgE production by B cells
  • IgE bind to mast cells and basophils à local allergic response
  • Recruitment of eosinophils
  • Induction of airway hyper-responsiveness, mucus production, tissue damage

 

Presence of human DC, Mast Cells, Eosinophils, Basophils, Neutrophils in Lungs

 

Ovalbumin induced in hu-mouse

 

 

 

READ-OUTS:

  • Clinical monitoring
  • Flow cytometry on blood, brocho alveolar lavage fluid (BALF) and lung homogenates
  • IgE production in Serum
  • Cytokine production in plasma (Th2)

OVA challenge in hu-mouse models

 

  • hCD45 – Total human leukocytes

OVA challenge increases neutrophils, Mast Cells and Basophils in lungs of hu-mouse

 

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