Asthma hu-mouse models
Involvement of Immune Cells in Asthma
- Allergen captured by DC
- DC present antigen to T cells to induce Th2
- Th2 promote IgE production by B cells
- IgE bind to mast cells and basophils à local allergic response
- Recruitment of eosinophils
- Induction of airway hyper-responsiveness, mucus production, tissue damage
Presence of human DC, Mast Cells, Eosinophils, Basophils, Neutrophils in Lungs
Ovalbumin induced in hu-mouse
READ-OUTS:
- Clinical monitoring
- Flow cytometry on blood, brocho alveolar lavage fluid (BALF) and lung homogenates
- IgE production in Serum
- Cytokine production in plasma (Th2)
OVA challenge in hu-mouse models
- hCD45 – Total human leukocytes
OVA challenge increases neutrophils, Mast Cells and Basophils in lungs of hu-mouse
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Find out about our Disease Models:
- Cancer/Immuno-oncology/PDX
- Infection-HIV
- Inflammation – IBD
- Vaccine – Immunization
- GvHD
- Asthma
- Hu-liver
- Immuno-Safty – Toxicity (non-GLP)
- Models in development – Protocol design
HUMAN IMMUNE SYSTEM hu-mouse models
