GvHD Induction using Immuno-Deficient Mouse Models engrafted with human PBMCs

PBMC from healthy donors are injected in NCG mice – Monitoring of the survival curve and Global clinical score

Exemple using Cyclosporine A treatment in n=12 mice per group (8-week old), 3 PBMCs donors randomised in the study.

 

  • Cyclosporin-A treatment significantly reduced the mortality and the global clinical score as compared to the vehicle group (PBS)
  • Circulating CD8+ T lymphocytes are decreased by Cyclosporin-A treatment

GVHD Global Clinical Scoring composed of six Scales: 

 

Immuno Profiling post-GVHD Induction 

Circulating CD8+ T cells are decreased by Cyclosporin A treatment (at D26)

 

 

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