Vaccine/Immunization
The full reconstitution of a functional human immune system in hu-mouse, despite a little thymus, allows the generation of full immune responses to any antigen on this naïve human immune system. Onco-foetal, developmental, weak, transmembrane, multimeric, DNA, protein, cell extract Ag’s can be recognized by the naïve human immune system in hu-mice to generate 100% full human IgG responses with a human size-like repertoire diversity. Isotype class switching (IgG1-2-3-4, IgE, IgA and IgM), 1011 diversity size comparable to human B cells responses, all looks very attractive to profile your drug for immune responses (vaccines) and to generate new biological drug therapeutics in the form of 100% human IgG mAb’s.
The full human immune system reconstitution for immunization
Uniqueness of the hu-mouse Models for Vaccines/Immunization
- Genuine human mAb’s against any antigen including ‘difficult targets’:
- e. g. oncofoetal, developmental, multiple subunits, cytoplasmic, Ebola, H1N1, …
- Ig Class Subtype Switching (IgG1-4, IgM, IgA, IgE responses)
- Non-chimeric, no blind spots in the large repertoire (not inbred)
- No tolerance to most difficult antigens (naïve human immune systems)
- Fully functional humoral human responses/large repertoires
- (as in humans, unlike current transgenic animal models)
- In vivo natural selection and maturation of the best immunoglobulin molecules
KLH Vaccination Protocol in Boosted hu-House



Find out about our Disease Models:
- Cancer/Immuno-oncology/PDX
- Infection-HIV
- Inflammation – IBD
- Vaccine – Immunization
- GvHD
- Asthma
- Hu-liver
- Immuno-Safty – Toxicity (non-GLP)
- Models in development – Protocol design