Sometimes, getting back to basics means leveraging conventional immunocompetent mouse models – such as C57BL/6 or BALB/c – to generate clear, reliable preclinical data. With over 12 years of experience, TransCure BioServices has developed deep expertise and full capabilities to design and execute high-quality studies using these models across oncology, infectious diseases, and inflammatory conditions.
Whether used as a foundational step or in parallel with our advanced humanized models – including the CD34⁺ Human Immune System Model, the TK-NOG Humanized Liver Model, and the Double Humanized Model combining both immune and liver humanization – our conventional mouse studies are conducted with the same scientific rigor, flexibility, and transparency that define our approach.
Main characteristics
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Oncology
Syngeneic tumor models, involving mouse-derived tumor cells implanted into immunocompetent mice, provide valuable insights into tumor growth and immune system interactions within an intact murine immune environment.
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Inflammation
TransCure’s models for IBD, MASH, asthma, allergy, and lung fibrosis can also be adapted to conventional immunocompetent mouse strains. These well-established models offer a valuable and cost-effective alternative for early-stage studies, enabling robust evaluation of efficacy, inflammation, and disease progression within a fully functional murine immune system.
Uncover disease areas for your humanized mouse studies
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IBD
Explore inflammatory bowel disease mechanisms and validate immunomodulatory compounds targeting human immune cells
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MASH
Study the progression of metabolic-associated steatohepatitis and evaluate therapeutic candidates in a human liver context and/or in the presence of a fully functional human immune system.
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Lung inflammation
Assess respiratory inflammation and immune-mediated lung disorders using Humanized Immune System mouse model.
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